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If a medication regimen leads to such severe appetite suppression that it causes malnutrition, muscle loss, and extreme fatigue, it can be counterproductive to the broader health objectives

Use with caution to the patient who is having adrenal insufficiency, autonomic neuropathy and receiving beta-adrenergic blocking agent Vitamin B12 deficiency Prolonged use of metformin can interfere in the absorption of vitamin b12 in the stomach

Although the DSM-IV [44] does not explicitly define residual schizophrenia, it describes as typical a course of the illness in which positive symptoms diminish while negative symptoms persist

Drug Development & Delivery

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