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These alterations create a vicious cycle of mitochondrial dysfunction, oxidative injury, and myofiber apoptosis, ultimately leading to irreversible supraspinatus atrophy and impaired regeneration after rotator cuff tears

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Specifically, the hGH protein in this study was isolated from cadavers (not made recombinantly) and so the observed impact on immunogenicity may differ from the modern products available today

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