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The presence of AD in these models was assessed based on the detection of two core biomarkers: (1) amyloid-beta (a ) plaques and (2) NFTs of abnormally phosphorylated tau proteins (Jack et al ., Reference Jack, Andrews, Beach, Buracchio, Dunn, Graf, Hansson, Ho, Jagust, McDade, Molinuevo, Okonkwo, Pani, Rafii, Scheltens, Siemers, Snyder, Sperling, Teunissen and Carrillo2024)