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National Academy of Recording Arts and Sciences

NRVMs were exposed to different concentrations of nicotine for 48 h, and cleaved caspase-3 and cleaved PARP were significantly increased with nicotine treatment (Figures 6AC)

When you inhale the aerosol vapor produced by these devices, you are also inhaling the fine particles of these ingredients

Participants were young adult nonsmokers ( n = 61 ADHD, n = 75 Control) between the ages of 1825 years (inclusive) who reported never having smoked a full cigarette, and no tobacco use in the prior 3 years

The most explicit answer to this question can be found in a 2024 article that considers the issue, explaining that heating tobacco yielded an aerosol but did not produce substances that the body could use as calories--and that flavour aerosols were inhaled, not used