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For many phytochemicals, the shift from benefit to harm occurs when their role changes from a mild stressor that triggers adaptive signaling to a direct participant in cellular disruption

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

In the db/db diabetic mouse model, mice in the low-iron diet group showed lower urinary protein excretion, renal MDA levels, and oxidative stress than those in the normal diet group [227]

They are working different jobs at different locations in the body