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Potential Side Effects and Risks Both medications may cause similar side effects, including: Nausea Diarrhea Constipation Low blood sugar (when combined with insulin or sulfonylureas) Additional risks for Tirzepatide may include: Increased gastrointestinal discomfort during the initial adjustment period Possible allergic reactions Always report any severe or unusual symptoms to your healthcare provider immediately

As of 2024, Medicare covers semaglutide 2.4 mg only when prescribed for cardiovascular risk reduction following the SELECT trial data, per CMS guidance [19]

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GLP-1 receptor agonist drugs mimic that hormone, which is why theyre so effective at reducing appetite and helping people lose significant amounts of weight