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Overall, it can be concluded that ROS play a crucial role in the modulation of the expression, activity, and localization of histone proteins that affect the epigenetic landscape both during development and disease (Table 3)

It comes from a 2010 meta-analysis of Social Relationships and Mortality Risk (see Figure), which benchmarked the size of the effect that lacking social connection has on risk for premature mortality against the effect of other known risk factors, including smoking

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