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The ban is part of an amended Health Promotion Law passed in 2018, and it applies to all restaurants and bars across Japan but exempts establishments that sell tobacco, such as cigar bars, and some small bars and restaurants

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Tolerance: The body may adapt the nicotine levels and require stronger doses or more frequent exposure to achieve the same pleasurable reward feeling

Acknowledgements The authors are grateful to Jennifer Bombard, MSPH and Ruben A Smith, PhD at the Division of Reproductive Health (CDC), Michelle OHegarty, PhD at the Office on Smoking and Health (CDC), and Van Tong, MPH at the National Center for Birth Defects and Developmental Disabilities (CDC) for their advice and guidance on our analysis of PRAMS data

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