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There is evidence that BCAAs can promote EC dysfunction by increasing oxidative stress and inflammation, but the specific enzymes, transporters, and pathways involved as well as the context-dependent effects require further investigation to fully elucidate their contribution to atherosclerosis development

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These limited reports suggest good tolerability, though the small sample sizes, lack of standardized safety monitoring, and retrospective or uncontrolled study designs limit definitive safety conclusions

Treibel TA, Manisty C, Burton M, McKnight , Lambourne J, Augusto JB, et al