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The smoking prevalence in Taiwan IBD patients is in accordance to the results from WHO, with the age-standardized prevalence of tobacco smoking in 2016 for both sexes globally being 19.9%, lowest at 9.8% in Africa, highest at 29.4% in Europe, and intermediate at 16.9% in South East Asia 2

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The thalamic region, which is abundant in neuronal nicotinic acetylcholine receptors (nAChRs), is responsible for the attention-improving effects of nicotine