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(Courtesy Duke Manuscript Collection / Digital Durham Looking southwest, 1920s, at Old Bull, the Hill Warehouse, the old power plant, Lucky Strike, and Reed

The epithelial changes in COPD are varied, including Goblet cell metaplasia, squamous metaplasia, and basal membrane thickening [48,49,50]

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As an initial step, we explored a model of cancer risk associated with direct dermal contact with bedding material containing NNK, a specific THS carcinogen (see Supplemental Materials: Preliminary Cancer Risk Estimation, Figs

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