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A total of 4,744 participants (2,162 men and 2,582 women) were included and were categorized into five groups (Non-smokers, E-cigar non-users in past-smokers, E-cigar users in past-smokers, E-cigar non-users in cigarette-smokers and E-cigar users in cigarette-smokers)

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Procedure for determination of nicotine content in smokeless tobacco products Nicotine is extracted from the smokeless tobacco with a mixture of n-hexane, sodium hydroxide solution, and water