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Pharmacotherapy is important in smoking cessation because quit-smoking medications promote long-term abstinence by easing tobacco withdrawal symptoms and blocking nicotines positive reinforcing effects without producing significant adverse side effects, according to a 2023 article by Pajai et al., published in the journal Cureus , titled Pharmacotherapy in Tobacco Cessation: A Narrative Review . Additionally, medications like varenicline disrupt the neurobiological pathways implicated in tobacco addiction and have been found to be effective even in patients who are unwilling to quit, according to a 2022 article by Gaddey et al., published in the journal American Family Physician , titled Smoking Cessation Interventions .