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With respect to the exciting causes we can only say, as when speaking of so-called spontaneous variations, that they relate much more closely to the constitution of the varying organism, than to the nature of the conditions to which it has been subjected

That wider definition would include e-cigarette liquid and most products, other than premium cigars and hookah tobacco

In other European countries, the impact of cross-border sales can be even more pronounced, which highlights the challenge of relying solely on legal sales volumes to estimate product substitution effects or changes in prevalence within a country

It ranks 8th in cancer mortality, with an estimated 83,190 new cases and 16,840 deaths in 2024, and a mean age at diagnosis of 73 years [8]

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