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The nicotine in e-cigarettes and other tobacco products can make it more likely that a teen or young adult can become addicted to other drugs

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It has been shown that CS induced hypermethylation of the Runt-related transcription factor 3 ( RUNX3 ), Janus kinase 3 ( JAK3 ) and keratin 1 ( KRT1 ) genes in people deficient for Alpha - 1 antitrypsin, which is associated with C-reactive protein ( CRP ) levels [107]

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