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Another systematic review and meta-analysis published in Tobacco Induced Diseases reported a similar increased risk of ED among smokers, with current smokers having a 1.5 to 2 times higher likelihood of experiencing ED compared to non-smokers

However, this correlation was reversed in smokers after OXT administration, suggesting that the interaction between nicotine addiction and OXT occurred in the process of subjective psychosocial stress coping, related to the anterior rSTG and its connectivity with the rMFG

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The elevated expression and release of SASP factors contribute to the initiation and progression of age-related diseases [40, 41]