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Bupropion requires dose reduction or avoidance in significant hepatic impairment and is contraindicated in people with a history of seizures

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Smoking coronary heart disease , one of the leading causes of death in the U.S a heart attack , as smoking damages blood vessels blockages that reduce blood flow to the skin and legs stroke due to blood clots or burst blood vessels in the brain Carbon monoxide and nicotine make the heart work harder and faster