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In contrast, S-15535 is a partial 5-HT 1A R agonist, which acts functionally as an antagonist at postsynaptic receptors, but as an agonist at presynaptic autoreceptors (46)
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Over the course of a roughly 90-minute performance, Bieber brought several new guests to the party including Sexyy Red on Sweet Spot, and an adorably sweet cameo from Billie Eilish at the end of One Less Lonely Girl. The special drop-ins continued with back to back songs with Big Sean (As Long As You Love Me, and No Pressure)