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In infected plants SA induces defense gene expression via the redox-dependent activation of the essential transcription regulator protein NPR1

Compared to Supersomes, human S9 and hepatocyte-based assays showed slightly improved metabolite coverage with human liver microsomes providing the closest representation of human in vivo amide hydrolysis (differing from in vivo metabolism in the cases of acetanilide, paracetamol and lidocaine)

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Initial in-Vivo Investigations Initial efforts to translate these in vitro findings into in vivo models have already been undertaken

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