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All patients attempting to quit using tobacco should be encouraged to use effective pharmacotherapies (Table 3) for smoking cessation, 43 except when medically contraindicated or in specific populations in which there is insufficient evidence of effectiveness (e.g., pregnant women, smokeless tobacco users, light smokers, adolescents)

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The first general inspection law in Virginia was passed in 1619 and provided that all tobacco offered for exchange at the magazine, the general storehouse in Jamestown, found to be very "mean" in quality by the magazine custodian was to be burnt

One of the most comprehensive studies supporting these findings was the EAGLES trial, one of the largest comparative studies of smoking cessation treatments ever conducted

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