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Additionally, CYP2A and CYP3A5 are downregulated in the airway of smokers [272, 275]

A UK-regulated disposable vape with the highest legal nicotine level (20mg/ml) contains 2ml of liquid and 40mg of nicotine

There is no safe level of secondhand smoke exposure according to the CDC

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A systematic review and meta-analysis published in 2018 further concluded that an association does exist between passive smoking and a greater presence of caries in children, both in primary and in permanent dentition (26)