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Nicotine is derived from tobacco leaf, and because it is addictive, it plays an important role in facilitating tobaccos harms

Overall, nicotine affects numerous systems, including the cardiovascular, neurologic, endocrine, and musculoskeletal systems (Figure 6)

Bahreinifar S, Sheon NM, Ling P

All species of Nicotiana contain the addictive drug nicotinea psychostimulant alkaloid found in all parts of the plants except the seeds, and most heavily concentrated in the leaveswhich occurs in varying amounts depending on the species of Nicotiana grown