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The usual mechanistic explanation is that the GHRH arm drives somatotroph cAMP signalling while the GHRP arm additionally attenuates somatostatin tone, so the two are acting on different limbs of the same axis rather than competing for one receptor

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Int J Obes (Lond) (2008) 32(10):155965.10.1038/ijo.2008.135 137 AliAHYanoffLBSternEAAkomeahACourvilleAKozloskyMet alAcute effects of betahistine hydrochloride on food intake and appetite in obese women: a randomized, placebo-controlled trial