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Mouse models have also confirmed that e-cigarettes increase immune cells like macrophages and neutrophils, as well as multiple COPD-related cytokines, including CCL2, IL-4, IL-13, IL-10, M-CSF, and TNF-

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But the most important and obvious change happened of course with the smoke flavor

In May, he said, "Our ambition is that more than half of our net revenues will come from smoke-free products in 2025." Philip Morris International is not affiliated with Philip Morris USA, which sells Marlboro in the U.S., where the brand has more sales than the next seven leading competitors combined