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We estimated the number (with NHANES sample weighting applied to estimating the population in millions) and proportion of individuals in our projected US population sample who would be eligible for semaglutide based on the STEP 1 trial criteria and who are in the overweight (BMI 27 kg/m 2 with known risks as described above) or with obesity (BMI of 30 kg/m 2 ) categories, and by sex and ethnicity

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This need to be in control, or autonomy, is the most essential driver of intrinsic motivation.8 The challenge, therefore, is to design a drug delivery solution that maximises that sense of autonomy while also maintaining the simple workflow that autoinjectors offer

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