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SGLT2 Inhibitors (SGLT2i): 3.1 Mechanism of Action: SGLT2 inhibitors (commonly known as -flozin drugs) work by blocking the SGLT2 protein in the proximal tubule of the kidneys

Nature Medicine (2024) 4

GLP-1 RAs promote satiety, reduce hunger, and dampen reward responsivity, which conceptually could open a temporary low-drive window during which behavioral techniques such as stimulus control, self-monitoring, and structured eating routines become more achievable

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