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Evidences for metabolic alterations of AMs in COPD are summarized in Table 2

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Risk was higher among smokers who began before age 15 compared to those who began at older ages, and the risk was highest of all for those who began smoking before age 10

During the second half of the 20th century, the adverse health effects of tobacco smoking started to become widely known and text-only health warnings became commonplace on cigarette packets

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