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McGoldrick, S., OSullivan, S

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These electrophilic modulators mainly interact with C151 in KEAP1, thereby inhibiting NRF2 ubiquitination and increasing the activity of ARE-mediated antioxidant and detoxifying enzymes [280]

The explanation for this observation is not established, but it has been suggested that some hemoglobin may be regurgitated from macrophages when the rate of phagocytosis of erythrocytes or erythrocyte fragments reaches a maximum ( 94 )

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