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Nicotine, the addictive substance found in tobacco, interacts with the brain in intricate ways

Priti Bandi, scientific director, risk factors and screening research at the American Cancer Society and lead author of the study

Crossover trials are different than parallel RCTs in a number of ways

In contrast, results from retail surveillance in the first test market for VLN suggest that 22 nd Century is leveraging its MRTP authorization for its brand with strategies mimicking retail marketing of high-nicotine cigarettes, though with some competitive challenges

"Just replacing your source of nicotine is not the key here." He noted that most smokers who tried e-cigarettes to quit didn't use high-nicotine vapes