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Cells exposed to 10% CSE showed an upregulation of IL-8 and CXCL2 expression (Figure 6C) , implying a contribution of bronchial epithelial cells to attract neutrophils

In humans, it has a very short half-life and is rapidly metabolized by liver enzyme CYP2A6 into cotinine and OH-Cotinine, which in turn can be utilized as clinical biomarkers to assess smoking-status 55

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BMC Public Health 24, 2301