It is established that miRNAs are key players in modulating macromolecular complexes in neurons, glia, and immune cells
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In line, miR-29a, b, c are also involved in regulating PER genes, -secretase (BACE1) mRNA and A accumulation (Mller et al., 2016)
The NAD + -consuming enzymes produce NAM as a byproduct, of which high concentrations inhibit the activity of NAD + -consuming enzymes, providing feedback regulation
