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Regarding the treatment of EMs, several flavonoids, such as quercetin, naringenin, baicalein, and wogonin, exert therapeutic effects by inducing apoptosis, primarily through cell cycle arrest induction, endoplasmic reticulum stress activation, ferroptosis inhibition, and mitochondrial function disruption, thereby triggering apoptosis (Figure 3)

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Electronic address eee, Clinical Practice Guideline Panel C, Panel m, representative EGB

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It may act as a trigger for localized cell death (HR) but also as a rapid signal for induction of antioxidative defenses