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Manufacturers often imply or even claim that spit or smokeless tobacco can help people quit smoking

"Nicotine patches help to relieve these withdrawal symptoms," says Ugo Iroku, MD, a physician with his own private practice

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Despite this, singers, actors and influencers seem to be bringing smoking back into vogue - quite literally, with cigarettes making a return as on the New York Fashion Week runways earlier this year as accessories

We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)