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This helps them expand their product lines, especially in obesity and type 2 diabetes
Compound 28 is a new quinoxaline-2,3-dione derivative synthesized from N-[2,3-dioxo-6-(phenylethynyl)-3,4-dihydroquinoxalin-1(2H)-yl] benzamide as a lead structure, which is a competitive GluK3 antagonist with sub-micromolar affinity and unprecedentedly high binding selectivity, with 400-fold higher selectivity for GluK3 than for other cognate receptors, and no agonistic or antagonistic activity in mGluRs isoforms [186]
Updates & Corrections Clarification 16 April 2025 : An earlier version of this article referred to Merck as a multinational company
[DOI] [PubMed] [Google Scholar] Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, Liu B (2002) Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinsons disease
Disulfide formation in the ER and mitochondria: two solutions to a common process
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