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SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

Heat stress can induce a systemic inflammatory response, promoting the production of inflammatory factors such as TNF-, IL-6, IL-1, and the TLR4/NF-B signaling pathway is also involved in mediating the inflammatory responsein rat heatstroke model, the interaction between TLR4 and its ligands on the cell membrane initiates downstream signals, triggering inflammation [27]

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