For a complete dosing reference, see the peptide dosage chart
Tirzepatide is a dual-agonist , meaning it works by targeting two hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Retatrutide is a triple-agonist , meaning it targets three hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Glucagon: affects energy use and fat metabolism Early studies show that retatrutide may be more successful than tirzepatide at managing diabetic kidney disease, as well as for weight control, while tirzepatide may be better at managing blood glucose
Semaglutide can be injected with or without food
When you combine them, you are not doubling the side effects, but you are increasing the likelihood of experiencing them, particularly during the adjustment period when your body is getting used to both
You can read more about the shared active ingredient and how both brands work in our hub article on tirzepatide and hair loss