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The summary relative risk of developing bladder cancer for 1 more cigarettes/day (7 cohorts and 24 casecontrol studies) was 1.039 (95% CI 1.0381.040, I 2 = 0%), for 1 more pack-year (3 cohorts and 21 casecontrol studies) was 1.017(95% CI 1.0161.019, I 2 = 0%) and for 1 more year of exposure (16 casecontrol studies) was 1.021 (95% CI 1.0201.023, I 2 = 0%)

There are going to be smokers in the UK for another 30 or 40 years, but there's no reason for people to smoke anymore

The honest collector's answer is: do as little as possible

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These products are often placed directly in the mouth, exposing gum tissue to concentrated doses of nicotine and carcinogens