CNS lipids are susceptible to oxidative damage (Niki, 2014) and lipoperoxidation generates high levels of HNE, MDA (Radak et al., 2011) and F2-isoprostane (F2-IsoPS) (Milne et al., 2007

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For example, those predicted to have a low early IGF-I response could start treatment on a higher r-hGH dose and have their r-hGH dose adapted based on levels of serum IGF-I assessed on a monthly basis, for a few months, following initiation of treatment
Advances Pharmacological Sciences
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