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Our study has conclusively demonstrated that cigarette smoke exposure has a profound suppressive effect on the generation of adaptive immune responses to NTHI and suggests the mechanism by which prior cigarette smoke exposure predisposes chronic obstructive pulmonary disease patients to recurrent infections, leading to exacerbations and contributing to mortality

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Talaat Atchabarov Scientific-Research Institute of Fundamental and Applied Medicine, Kazakh National Medical University, Almaty, Kazakhstan Dimash Davletov, Timur Saliev & Abzal Zhumagaliuly Population Health Research Center, Kazakh National Medical University, Almaty, Kazakhstan Kairat Davletov Department of Public Health, National University of Colombia, Bogota, Colombia Fernando Pio De la Hoz Department of Medicine, North Bengal Medical College and Hospital, Siliguri, India Novonil Deb Memorial Sloan Kettering Cancer Center, New York, NY, USA Edward Christopher Dee Department of Forensic Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina Emina Dervievi Department of Public Health, Debre Tabor University, Debre Tabor, Ethiopia Aragaw Tesfaw Desale Public Health and Environment Research Centre (PERC), Lalitpur, Nepal Keshab Deuba Global Health Epidemiology Research Group, University of Bergen, Bergen, Norway Keshab Deuba Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK Arkadeep Dhali Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India Kuldeep Dhama Neurology Department Institute of Human Behavior and Allied Sciences, University of Delhi, New Delhi, India Rajinder K