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Attribution incorporates text from a publication now in the public domain: Chisholm, Hugh, ed

70 The RESTORE study, a prospective randomized, double-blind, placebo-controlled study of patients with GOLD stage II and III COPD, showed that patients who received erdosteine 300 mg twice daily added to usual treatment reduced exacerbation rates by 19.4% (0.91 versus 1.13 exacerbations/patient/year, p =0.01), mostly due to a reduction of mild exacerbations