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Direct comparative studies are needed to rigorously assess the relative cardiovascular risk profile of nicotine pouches versus cigarettes, E-cigarettes, and traditional smokeless tobacco, using both biomarker and clinical endpoints

[] We also estimated a model of Equation 1 directly which includes smoking prevalence, a time trend, and all our smuggling variables included in the second stage of our model

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Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium