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Products like e-cigarettes and nicotine pouches arent considered safe, but they are significantly less risky than combustible cigarettes

Second, we estimated multivariable linear regression models of cigarettes smoked per day, conditional on the frequency of vaping (categorized as every-day, some-days, ever but no longer, never), psychological distress (categorized as NPD, MPD, and SPD), the interaction of vaping and psychological distress (these variables were demeaned, or centered so that main effect coefficients could be directly interpreted 26 ), and other covariates described above

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3 confirms that there is virtually no separation between the two compounds, and the rise of the peaks was sufficiently fast to discriminate peak shape differences in relation to a 2-s puff

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