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I think that just seeing this pattern at all is very concerning and it would hopefully discourage nonsmokers from taking up electronic cigarettes. Middlekauff said it was reassuring, however, that non-nicotine components do not have an obvious effect on adrenaline levels in the heart

Potential confounders included sex, age, race/ethnicity, education, household income, body mass index (BMI) (a measure of body fat based on weight and height), disease status, overall tobacco use, marijuana use, and secondhand smoke exposure

- Among women who use oral contraceptives, those who smoke have a particularly high risk of coronary heart disease

Additionally, these products may contain other chemicals, the long-term effects of which are not well understood