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A cohort study found that 18 of 283 (6.4%) individuals with RDEB had a diagnosis of SCC with a median age of diagnosis of 22.6 years (interquartile range, 2027.7 y).[145] Early mortality also has been observed in this disorder, with a mortality rate of up to 40% by age 30 years.[146] An epidemiological study in Germany found that the mean age of death was 28.03 years in patients with DEB.[130] Extracutaneous manifestations of RDEB-sev gen include short stature, anemia, strictures of the gastrointestinal and genitourinary tracts, and corneal scarring that may result in blindness
The peptide requires refrigeration and careful handling due to its complex structure
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The mechanism is real, the evidence is consistent, and the dosing window is narrow