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Molecular and Cellular Proteomics, 11 (11), 1354-1364

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Although in vitro studies suggest that tirzepatide exhibits lower GLP-1 receptor activation compared to native GLP-1 [74], it is hypothesized to stimulate the GLP-1 receptor more strongly than semaglutide due to its biased agonism and higher dosing regimen (tirzepatide: 2.515 mg/week vs