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The high specificity toward cysteine from other amino acids and biomolecules was due to its mercapto group that binds to the surface of CuO NPs and the electrostatic interaction between the cysteine zwitterions on the surface of CuO NPs

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Furthermore, these increased levels of pro-inflammatory cytokines resulted in an increase of corticotropin-releasing hormone activity and hyperactivity of the HPA axis in most patients with depression (Kopschina Feltes et al., 2017)

For a more visual breakdown of how these systems interact, you can always check out our YouTube channel, where we explore these topics in greater detail