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Finally, we highlight therapeutic agents targeting both processes, suggesting novel treatment directions

Mother Nature created triglycerides to be easily hydrolyzed (be broken down to a glycerin + 3 fatty acid molecules) and oxidized (the fatty acid is broken down into small parts) - this happens basically when we eat fats or oils and our body generates energy from it

These factors should inform shared decision-making between patient and provider, not necessarily contraindicate GLP-1, but justify closer monitoring during dose escalation

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FIGURE 2 FIGURE 3 GPR30/GPER-1: A Non-classical Estrogen Receptor Initially, GPR30 (G protein-coupled receptor 30) was considered an orphan receptor (Revankar et al., 2005)