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Just asked, months later, whether they felt better [14]

A similar effect has been observed in the sera of Caucasian patients receiving iron therapy for the treatment of -thalassemia, where GSTT1 and GSTM1 genes were down regulated [76]

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It is reported that high concentrations of fumarate and succinate can enhance the 3-methylation of histones H3K4 and H3K27 by inhibiting KDM5 histone demethylase (responsible for H3K4 demethylation) and JMJD3 histone demethylase, respectively, which in turn promotes the expression of pro-inflammatory cytokine genes (99, 115, 125, 161, 162)