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(PDF) Acknowledgments We thank Melanie Marty, David Kessler, Paul Blanc, John Froines, and Neal Benowitz for helpful comments on the manuscript

at once furious, heartbreaking, contemplative, joyous, and moving

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It demonstrates our commitment to enabling the development of safe and effective product innovations that may help smokers quit combustible cigarettes and improve their health. This guidance includes several innovations in the regulatory pathway for NRT drug products