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Identified metabolites were annotated using the KEGG Compound database ( and mapped to pathways in the KEGG Pathway database ( Pathways containing significantly regulated metabolites underwent metabolite set enrichment analysis (MSEA), with significance assessed using p-values from hypergeometric tests

Due to the inhibition of platelet functions after exposure to pure nicotine, it is believed that other components of ECV can antagonize platelet functions

These are: Naltrexone: It is an opiate blocker that blocks opioids from acting on the brain

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The 1st December 1932 issue contained the last article within the series which focused on the Imperial Tobacco Co